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KMID : 1134820170460040490
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Journal of the Korean Society of Food Science and Nutrition
2017 Volume.46 No. 4 p.490 ~ p.500
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Safety Evaluation of Ethanol Extract from Unripe Fruit of Bitter Melon (Momordica Charantia L.) in Sprague-Dawley Rats
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Ryu Hyeon-Yeol
Lee So-Min
Ahn Kyu-Sup
Yeon Yong
Kim Hye-Jin
Kim Seong-Eun
Lee Hak-Sung
Hong Su-Young
Kim Hyun-Kyu
Hwang In-Guk
Song Kyung-Seuk
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Abstract
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This study was performed to evaluate repeated dose oral toxicity upon administration of the test substance 1,2-benzisothiazolin-3-one for 90 days and to determine NOAEL (no observed adverse effect level) and target organs in Sprague-Dawley rats. Single, 2-week repeated, and 13-week repeated oral dose toxicity studies were conducted in Sprague-Dawley rats. The dose levels of groups were 1,250, 2,500, and 5,000 mg/kg/d. All dose groups were compared with the vehicle control group. The animals were observed for clinical signs and weekly body weight. Urinalysis, hematology, and serum biochemistry analyses were conducted. Subsequently, animals were sacrificed and subjected to histopathological examination. For the result, NOAEL of ethanol extract from unripe fruit of bitter melon had an optimal dose of 5,000 mg/kg/d and acceptable daily intake up to 3,000 mg/man. There was no target organ detected. Therefore, bitter melon, which contains a variety of bioactive substances, could be widely used as a health functional food ingredient.
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KEYWORD
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Momordica charantia, bitter melon, safety evaluation, NOAEL
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